Richard,
 I've been using a 1D MkIIn for the past year or so, compared to the 450D 
it has fewer MP, much higher frame rate a much much nicer viewfinder, 
much quicker autofocus and the images are generally less noisy.  All 
this applies to the 1D MkIV which has a higher still frame rate and more 
MP.  The 7D also has a similar frame rate.  The 450D uses a pentamirror 
rather than a pentaprism, to relay the image from the focus screen to 
the viewfinder the result is a rather dim viewfinder, the 7D and 1D 
cameras us a pentaprism.  The 1D series have excellent focus screens and 
are a joy to use and you can easily manuallly focus if desired.  The 
cheaper cameras can be quite difficult to manual focus as the screen is 
designed for brightness rather than focusing snap.
 The 1D series use a 1.3x crop factor sensor, which is 28.7 x 19mm, the 
7D and 450D have a 22.2 x 14.8 mm sensor with a 1.6x crop factor.  The 
difference besides having a wider field of view with the bigger sensor 
is that bigger sensor gathers more photons of light and generates give 
or take the same amount of electronic noise per pixel.  So the big 
sensor has better signal to noise than the small sensor.  What I find is 
this translates to being able to casual about exposure and being able to 
correct the files more readily in RAW before noise intrudes.  The 7D and 
also the 50D have have a bit of a reputation for being noisy unless you 
expose the image well, generally this means exposing to get the 
histogram all the way to the right without blowing highlights then 
correcting the image in the raw converter.  This link explains it further:
http://en.wikipedia.org/wiki/Image_sensor_format
 The other thing the 1 series cameras give is complete weather sealing 
and the provision of two card slots and a much more robust body overall, 
along with great long battery life and a built in vertical grip and 
shutter button.  Another addition is the ability to autofocus at f8 on 
the centre sensor, all other non 1 series canon  give up beyond f5.6, 
consequently they will AF in lower light and the 1 series also feature 
many more AF points to choose from, the MKII has 45 AF points.
 Another option to consider is the 5D MkII which has a full frame 36 x 
24mm sensor, very low noise, reportedly very good auto focus and image 
quality as good as it gets.  What you don't get is the frame rate, f8 
AF, built in vertical grip and weather sealing.
 If you want to extend your $ to buy some nice long glass, you could 
always check out what the cameras go for on Ebay.  1D MkIIn's go for 
about $1600 and MkIII's for about $2500 or so.  The MkIII has 10MP and 
great image quality and low noise at high ISO, but issues with 
autofocus, both for moving targets and static targets in high 
temperatures. which seems to vary from body to body, you want to be able 
to try out the AF before buying and preferably buy a late production 
example and confirm it has had the sub mirror fix, either built with it 
or has the mod done under warranty.  Having said that a lot of people on 
forums report they are very happy with their MkIIIs.  The MkII I have is 
8.2 MP and noise performance is good, I use ISO400 as a standard and 
ISO800 and 1600 are both good as long as well exposed.  The MKII's are 
heavier as they use a Ni-MH battery rather tan the Lithium batteries in 
later versions. 
hope that's helpful,
Chri Ross
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