Michael Brosch and Henning Scheich (2008): Tone-sequence analysis in the
auditory cortex of awake macaque monkeys. Experimental Brain Research,
184(3), 349-361.
Abstract: The present study analyzed neuronal responses to two-tone
sequences in the auditory cortex of three awake macaque monkeys. The monkeys
were passively exposed to 430 different two-tone sequences, in which the
frequency of the first tone and the interval between the first and the
second tone in the sequence were systematically varied. The frequency of the
second tone remained constant and was matched to the single-tone frequency
sensitivity of the neurons. Multiunit activity was recorded from 109 sites
in the primary auditory cortex and posterior auditory belt. We found that
the first tone in the sequence could inhibit or facilitate the response to
the second tone. Type and magnitude of poststimulatory effects depended on
the sequence parameters and were related to the single-tone frequency
sensitivity of neurons, similar to previous observations in the auditory
cortex of anesthetized animals. This suggests that some anesthetics produce,
at the most, moderate changes of poststimulatory inhibition and facilitation
in the auditory cortex. Hence many properties of the sequence-sensitivity of
neurons in the auditory cortex measured in anesthetized preparations can be
applied to neurons in the auditory cortex of awake subjects.
URL: http://www.springerlink.com/content/75682w522251015h/
For reprints please contact Michael Brosch (Email:
Kind regards
Sonja Amoser
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