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new article in Journal of Comparative Neurology

Subject: new article in Journal of Comparative Neurology
From: Dave Mellinger <>
Date: Fri, 28 Jan 2005 08:30:57 -0800
 Paul M. Forlano, David L. Deitcher, Andrew H. Bass (2005): Distribution of
 estrogen receptor alpha mRNA in the brain and inner ear of a vocal fish with
 comparisons to sites of aromatase expression. The Journal of Comparative
 Neurology, 483(1), 91-113
 Abstract: Among vertebrates, teleost fish have the greatest capacity for
 estrogen production in the brain. Previously, we characterized the
 distribution of the estrogen-synthesizing enzyme aromatase in the brain of
 the midshipman fish. Here, we investigated the distribution of estrogen
 receptor alpha (ER). A partial cDNA of ER was cloned and used to generate
 midshipman-specific primers for RT and real-time PCR which identified
 transcripts in liver and ovary, the CNS, and the sensory epithelium of the
 main auditory endorgan (sacculus). In situ hybridization revealed abundant
 expression throughout the preoptic area, a vocalacoustic site in the
 hypothalamus, amygdala homologs of the dorsal pallium, the pineal organ, the
 inner ear, the pituitary, and the ovary. Weaker expression was found in the
 midbrain's nucleus of the medial longitudinal fasciculus and in the
 dimorphic vocal motor nucleus. ER expression in the pineal, gonad, and
 pituitary axis may function to time seasonal abiotic cues to reproductive
 state, while expression in the vocal motor and auditory systems support
 neurophysiological evidence for estrogen as a modulator of vocal motor and
 auditory encoding mechanisms in midshipman fish. While ER is restricted to
 specific nuclei, aromatase expression is abundant in glial cells throughout
 the entire forebrain, and high in midbrain and hindbrain - spinal vocal
 regions. The only site of aromatase-containing neurons is in the peripheral
 auditory system, where it is localized to ganglion cells in the auditory
 nerve. Estrogen production proximal to ER-positive neurons may provide for
 focal sites of estrogen effects on reproductive-, vocal-, and
 auditory-related neurons.
 PDF is available via the following link:
 Sonja Amoser
 Sonja Amoser, PhD Student
 University of Vienna, Department of Behavior, Neurobiology and Cognition
 Althanstrasse 14, 1090 Vienna, Austria
 Phone: +43-1-4277-54467 oder +43-664-5006106 (private)
 Fax: +43-1-4277-54506

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