Fw: [APMW] Avian flu: Don't place all the blame onwild birds

To: Mark Gafney <>
Subject: Fw: [APMW] Avian flu: Don't place all the blame onwild birds
From: Andrew Taylor <>
Date: Fri, 26 May 2006 22:10:08 +1000
On Fri, May 26, 2006 at 12:34:35PM +0200, Mark Gafney wrote:
>  Do you know that against a SUPPOSED mutant virus such as H5N1,
> TAMIFLU will not work?

No because its not true.  RNA viruses have extremely high mutation rates
- so high that a majority of their genome replications might contain
mutations.  I don't quite understand how  RNA viruses  can persist
on evolutionary timescales but anyway, fortunately, anti-virals are
still possible.

Tamiflu (oseltamivir) is a neuraminidase inhibitor.  Neuraminidase plays
a key role in the replication of all Influenza A subtypes - its the N in
H5N1 and also Influenza B.  There was some evidence of H5N1 resistance
to oseltamivir appearing to but hopefully this will be slow to arise
because of neuraminidase's role in viral replication.

If you want to buy from different pharmaceutical multinational - there
is an alternative neuraminidase inhibitor: Relenza(zanamivir) which was
developed in Australia.

I'll leave the rest of the conspiracy theory alone.  Judging by a web
search its been very widely circulated.

I think the news about Newcastle Disease mentioned by Terry was that
a combined poultry vaccine for Newcastle Disease and H5N1 had been


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